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排序方式: 共有3246条查询结果,搜索用时 140 毫秒
31.
Myeongjoo Son Seyeon Oh Junwon Choi Ji Tae Jang Kuk Hui Son Kyunghee Byun 《International journal of molecular sciences》2021,22(8)
Hypertension induces renal fibrosis or tubular interstitial fibrosis, which eventually results in end-stage renal disease. Epithelial-to-mesenchymal transition (EMT) is one of the underlying mechanisms of renal fibrosis. Though previous studies showed that Ecklonia cava extracts (ECE) and dieckol (DK) had inhibitory action on angiotensin (Ang) I-converting enzyme, which converts Ang I to Ang II. It is known that Ang II is involved in renal fibrosis; however, it was not evaluated whether ECE or DK attenuated hypertensive nephropathy by decreasing EMT. In this study, the effect of ECE and DK on decreasing Ang II and its down signal pathway of angiotensin type 1 receptor (AT1R)/TGFβ/SMAD, which is related with the EMT and restoring renal function in spontaneously hypertensive rats (SHRs), was investigated. Either ECE or DK significantly decreased the serum level of Ang II in the SHRs. Moreover, the renal expression of AT1R/TGFβ/SMAD was decreased by the administration of either ECE or DK. The mesenchymal cell markers in the kidney of SHRs was significantly decreased by ECE or DK. The fibrotic tissue of the kidney of SHRs was also significantly decreased by ECE or DK. The ratio of urine albumin/creatinine of SHRs was significantly decreased by ECE or DK. Overall, the results of this study indicate that ECE and DK decreased the serum levels of Ang II and expression of AT1R/TGFβ/SMAD, and then decreased the EMT and renal fibrosis in SHRs. Furthermore, the decrease in EMT and renal fibrosis could lead to the restoration of renal function. It seems that ECE or DK could be beneficial for decreasing hypertensive nephropathy by decreasing EMT and renal fibrosis. 相似文献
32.
Jinhong Kim Junho Jang Sehui Yun Hyeon Deok Kim You Young Byun Yong Tae Park Jung Il Song Chungyeon Cho 《大分子材料与工程》2021,306(9):2100233
In an effort to develop highly functionalized flame retardant materials, hybrid nanocoatings are prepared by alternately depositing a positively charged polyaniline (PANi) and negatively charged montmorillonite (MMT) using the layer-by-layer (LbL) assembly technique. Carbon nanotubes (CNTs) are employed in polymer nanocomposites as effective reinforcement, where nanotubes are stabilized in MMT aqueous solution. The 3D structure and high density of CNTs deposited in the PANi/CNTs-MMT multilayers produce thicker and heavier coatings in comparison to the LbL assemblies without CNTs. Vertical and horizontal flame testing show that the incorporation of CNTs improves fire resistance. Additionally, cone calorimetry reveals that stacking two nanomaterials (MMT and CNTs) in a single coating shows a significant reduction in peak heat release rate (up to 51%), total smoke release (up to 47%), and total heat release (up to 37%) for the polyurethane foam. The enhancement of flame retardancy is attributed to a synergistic effect; MMT serves as a physical barrier that retards the diffusion of heat and gas. The addition of CNTs strengthens the thermal stability and high char yield. These results, coupled with the simplicity with which the LbL deposition is applied, present a viable alternative to halogen-free flame retardant nanocoatings to natural and synthetic fibers. 相似文献
33.
Jun T. Kim Dong S. Cha Gee D. Lee Tae W. Park Dong K. Kwon Hyun J. Park 《应用聚合物科学杂志》2002,83(2):423-434
Biodegradable plastics were produced from sweet potato pulp (SPP) and cationic starch (CS) or chitosan composite (CC) by compression molding and their mechanical properties were tested. A universal testing machine, Rockwell hardness tester, and Izod impact tester were used for testing the mechanical properties (flexural strength, Rockwell hardness, and Izod strength) of the plastics. A central composite second‐order design was used to study the effects of temperature, time, and moisture content on the flexural strength, Rockwell hardness, and Izod strength of SPP/CS and SPP/CC blended plastics. The flexural strength, Rockwell hardness, and Izod strength of SPP‐based plastics was 101.1–305.9 kg/cm2, R29.0–R96.7, and 0.6–3.0 kg cm cm?2, respectively. Regression analysis predicted the optimal mechanical properties (flexural strength, Rockwell hardness, and Izod strength) to be attained with a 150–160°C temperature, 15–20‐min reaction time, and 20–23% moisture content. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 83: 423–434, 2002 相似文献
34.
Dong Won Cho Young Hae Lee Tae Youn Lee Mitsuo Gen 《Journal of Intelligent Manufacturing》2014,25(5):1025-1042
In this paper we propose an adaptive genetic algorithm that produces good quality solutions to the time dependent inventory routing problem (TDIRP) in which inventory control and time dependent vehicle routing decisions for a set of retailers are made simultaneously over a specific planning horizon. This work is motivated by the effect of dynamic traffic conditions in an urban context and the resulting inventory and transportation costs. We provide a mixed integer programming formulation for TDIRP. Since finding the optimal solutions for TDIRP is a NP-hard problem, an adaptive genetic algorithm is applied. We develop new genetic representation and design suitable crossover and mutation operators for the improvement phase. We use adaptive genetic operator proposed by Yun and Gen (Fuzzy Optim Decis Mak 2(2):161–175, 2003) for the automatic setting of the genetic parameter values. The comparison of results shows the significance of the designed AGA and demonstrates the capability of reaching solutions within 0.5 % of the optimum on sets of test problems. 相似文献
35.
Tae Hwan Kim B. Ramachandra Jung Sik Choi M. B. Saidutta Ko Yeon Choo Sun-Dal Song Young-Woo Rhee 《Catalysis Letters》2004,98(2-3):161-165
Methanol selective oxidation to formaldehyde over a modified Fe-Mo catalyst with two different stoichiometric (Mo/Fe atomic ratio = 1.5 and 3.0) was studied experimentally in a fixed bed reactor over a wide range of reaction conditions. The physicochemical characterization of the prepared catalysts provides evidence that Fe2(MoO4)3 is in fact the active phase of the catalyst. The experimental results of conversion of methanol and selectivity towards formaldehyde for various residence times were studied. The results showed that as the residence time increases the yield of formaldehyde decreases. Selectivity of formaldehyde decreases with increase in residence time. This result is attributable to subsequent oxidation of formaldehyde to carbon monoxide due to longer residence time. 相似文献
36.
Sweet potato pulp (SSP) obtained as a by‐product from starch extraction was blended with polycaprolactone (PCL) to prepare a biodegradable plastic material. In the blends, PCL was used as a reinforcing agent. The SPP/PCL blends were prepared by compression‐molding under high temperature and pressure, at different SPP/PCL ratios, and the mechanical properties of the molded specimens were tested. Matrix structure and thermal properties were measured by using a Fourier transform infrared (FTIR) spectrophotometer, scanning electron microscope (SEM), differential scanning calorimetry (DSC), and thermogravimetric analyzer (TGA). Mechanical properties (tensile and flexural properties) were also measured to find the most suitable ratio in a SSP/PCL blend. During compression molding of the SPP/PCL blends under high pressure and temperature, chemical reaction occurred between SPP and PCL, and thus, thermal stability and mechanical strength of the blends increased and water uptake decreased. Also, by increasing the PCL content in the blend, the matrix in the blend became more homogeneous, and consequently, mechanical strength of the molded specimen increased. At 7/3 or 6/4 weight ratio of SSP/PCL, water uptake of the molded specimen became substantially less than that at 8/2. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 92: 861–866, 2004 相似文献
37.
The thermal and thermomechanical properties of two series of poly(ethylene oxide) networks (NPEOs) were investigated as a function of the chain length between crosslink sites (Mc) and the concentration of LiClO4 (CL) in the NPEOs. The two series of networks were produced with silica and organic crosslinking agents and, therefore, had crosslink sites of different natures: one was an inorganic silicate network (silica NPEO), and the other was an organic polar group (organic NPEO). The crosslink sites in both series of networks were commonly covalently bonded to the poly(ethylene oxide) (PEO) phase through a urethane group in the NPEOs. The glass‐transition temperatures (Tg's) of the PEO phases in the NPEOs, according to differential scanning calorimetry, increased with a decrease in Mc and were higher in the silica NPEOs than in the organic NPEOs under the same Mc conditions. The difference in Tg between the two series of networks with the same Mc values increased with decreasing Mc. These results suggested that the interaction of crosslink sites with the PEO phase was stronger in the silica NPEOs than in the organic NPEOs. The addition of LiClO4 to the NPEOs resulted in Tg of the PEO phase in the NPEOs being elevated and increased according to the increase in CL. The increase of Tg of the PEO phase according to the increase of CL in the NPEOs was retarded or saturated at high values of CL, and this indicated that the limit of solubility of the salt in the polymer was attained. The retardation or saturation of the increase of Tg was also observed in dynamic mechanical analyses. The curves of the loss factor tan δ and temperatures from the dynamic mechanical analyses for the NPEOs with high values of CL showed shoulders or double peaks indicating the existence of the second phase in the polymer networks. In the curves of tan δ for salt‐complexed NPEOs with high values of CL, silica NPEOs showed a shoulder of low intensity, but organic NPEOs showed a distinguished second peak becoming stronger with increasing CL. The results of the Tg behavior and tan δ curves suggested that the salt solubility in the NPEOs was limited and that the salt solubility of PEO in the silica NPEOs was higher than that in the organic NPEOs. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 270–277, 2003 相似文献
38.
The mechanical and thermal properties of interply hybrid carbon fiber (continuous and spun fabric)/phenolic composite materials have been studied. Hybrid carbon/phenolic composites (hybrid CP) with continuous carbon fabric of high tensile, flexural strength and spun carbon fabric of better interlaminar shear strength and lower thermal conductivity are investigated in terms of mechanical properties as well as thermal properties.Through hybridization, tensile strength and modulus of spun type carbon fabric reinforced phenolic composites (spun CP) increased by approximately 28% and 20%, respectively. Hybrid CP also exhibits better interlaminar shear strength than continuous carbon fabric/phenolic composites (continuous CP).The in-plane thermal conductivity of hybrid CP is 4-8% lower than that of continuous CP. As continuous filament type carbon fiber volume fraction increases, the transversal thermal conductivity of hybrid CP decreases.The erosion rate and insulation index were examined using torch test. Spun CP has a higher insulation index than continuous CP and hybrid CP over the entire temperature range. Hybrid CP with higher content of spun fabric exhibits higher insulation index as well as lower erosion rate. 相似文献
39.
Young Tae Moon Do Kyung Kim Chong Hee Kim 《Journal of the American Ceramic Society》1995,78(4):1103-1106
Based on the principle that the solubility of a salt decreases as the dielectric constant of the solvent decreases, zirconia powders were prepared by heating a zirconyl chloride solution with a 2-PrOH-water mixture as the solvent. The morphology, size, and size distribution of the resulting particles were highly sensitive to the heating method used on the starting solution. Particles formed under conventional heating methods were polydisperse, agglomerated spherical, or irregularly shaped because of inhomogeneous precipitation through the temperature gradient, the shear force induced by stirring, compositional nonuniformity, and the low heating rate. The present study demonstrated that microwaves provide an excellent means of heating uniformly and rapidly without stirring. The particles resulting from microwave treatment were monodisperse and spherical, with a mean diameter of 0.28 μm. 相似文献
40.
Tae?Joon?Chung Min?Chan?Kim Chang?Kyun?ChoiEmail author 《Korean Journal of Chemical Engineering》2004,21(1):41-47
The temporal development of thermal disturbances in the fluid layer heated isothermally from below is investigated, based
on propagation theory. This theory is examined by using scaling. To examine the behavior of thermal instability the mean-field
approximation is employed and resulting equations are solved by Galerkin method. The stability criteria to mark the onset
of convective instability are newly suggested as the intersection point of the growth rate of averaged temperature with that
of its fluctuation. The resulting critical time is close to that derived from propagation theory. By considering the nonlinear
effects, the characteristic times to represent the detection time of manifest convection and also to exhibit the minimum Nusselt
number are discussed. 相似文献